Protein degradation in health and disease / Ciba Foundation

Introduction: the clasification of proteinases -- Lysocomal cysteine proteinases -- Cathepsin D: the lysosomal aspartic proteinase -- Human leucocyte elastase and cathepsin G: structural and functional characteristics -- Human collagenases: comparative and inmunolocalization studies -- Proteinases in connective tissue breakdown -- Cellular mechanisms of proteinase release from inflamatory cells and the degradation of extracellular proteins -- Inactivation of cytosol enzymes by a liver membrane protein -- Lysosomes and protein degradation -- Insigths into mechanisms of intracellular protein turnover from studies on pinocytosis -- Turnover and degradation of mitochondria and their proteins -- Protein degradation in cells in culture -- Regulation of protein breakdown in hepatocyte monolayers -- A possible role for neutral proteolysis in the degradation of intracellular proteins -- Studies of the ATP dependence of protein degradation in cells and cell extracts -- Coordination of protein synthesis and degradation -- Application of liver perfusion as an in vitro model in studies of intracellular protein degradation -- Protein degradation and the regulation of protein balance in muscle -- Protein degradation in metabolic and nutritional disorders -- Proteinase inhibitors in severe inflammatory processes (septic shock and experimental endotoxaemia): biochemical, pathophysiological and therapeutic aspects -- Neutral proteinases of leucocytes and the inflammatory process -- Concluding remarks.